Mechanistic insights on the inhibition of tumor angiogenesis

  title={Mechanistic insights on the inhibition of tumor angiogenesis},
  author={Benilde Jim{\'e}nez},
  journal={Journal of Molecular Medicine},
Angiogenesis, the growth of new vasculature, is an absolute requirement for the maintenance and progression of the overwhelming majority of the solid tumors. Unraveling the mechanisms that govern this complex biological process has become a central issue not only for understanding of the molecular basis of cancer but also for developing new therapeutic approaches that interfere with neovascularization of the tumor mass. Here we discuss the survival and apoptosis of endothelial cells in the… CONTINUE READING
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