Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris.

@article{Rajendra2011MechanisticII,
  title={Mechanistic insights into the therapeutic use of high-dose allopurinol in angina pectoris.},
  author={Narasimharajapura S Rajendra and Sheila Ireland and Jacob George and Jill J. F. Belch and Chim C Lang and Allan D. Struthers},
  journal={Journal of the American College of Cardiology},
  year={2011},
  volume={58 8},
  pages={820-8}
}
OBJECTIVES The aim of this study was to evaluate the effect of high-dose allopurinol on vascular oxidative stress (OS) and endothelial function in subjects with stable coronary artery disease (CAD). BACKGROUND Allopurinol, a xanthine oxidase inhibitor, prolongs the time to chest pain during exercise in angina. We sought to ascertain whether allopurinol also improves endothelial dysfunction in optimally treated CAD patients, because such an effect might be of value to reduce future… CONTINUE READING

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