Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.

Jie Zhu; Mark S Hixon; Daniel Globisch; Gunnar F. Kaufmann; Kim D Janda

Chemistry, Medicine
Published in
Journal of the American…
2013
DOI:10.1021/ja4024989

Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.

@article{Zhu2013MechanisticII,
  title={Mechanistic insights into the LsrK kinase required for autoinducer-2 quorum sensing activation.},
  author={Jie Zhu and Mark S Hixon and Daniel Globisch and Gunnar F. Kaufmann and Kim D Janda},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 21},
  pages={
          7827-30
        }
}

Jie Zhu, Mark S Hixon, +2 authors Kim D Janda

In enteric bacteria, the kinase LsrK catalyzes the phosphorylation of the C5-hydroxyl group in the linear form of 4,5-dihydroxy-2,3-pentanedione (DPD), the precursor of the type II bacterial quorum sensing molecule (AI-2). This phosphorylation is required for AI-2 sequestration in the cytoplasm and subsequent derepression of AI-2-related genes necessary for quorum development. While LsrK is a critical enzyme within the DPD quorum sensing relay system, kinetic details of this kinase have yet to… CONTINUE READING

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