Mechanistic insights into nickel-catalyzed cycloisomerizations.


A nickel-catalyzed cycloisomerization coupling an allylic alcohol with an alkyne has been developed. Mechanistic insights gained through deuterium-labeling crossover studies and stereochemical probes illustrate that oxidation of the allylic alcohol to a metal-free enone is not involved in the cyclization pathway. The intermediacy of a metallacycle directly… (More)
DOI: 10.1021/ol101852w


Cite this paper

@article{Phillips2010MechanisticII, title={Mechanistic insights into nickel-catalyzed cycloisomerizations.}, author={John H. Phillips and John Montgomery}, journal={Organic letters}, year={2010}, volume={12 20}, pages={4556-9} }