Mechanistic insights into functional characteristics of native crotamine

  title={Mechanistic insights into functional characteristics of native crotamine},
  author={Daniel Batista da Cunha and Ana Vit{\'o}ria Pupo Silvestrini and Ana Carolina Gomes da Silva and Deborah Maria de Paula Estevam and F. L. Pollettini and Juliana de Oliveira Navarro and A. A. Alves and Ana Laura Rem{\'e}dio Zeni Beretta and J. M. Annichino Bizzacchi and L. C. Pereira and M. V. Mazzi},
  • Daniel Batista da Cunha, Ana Vitória Pupo Silvestrini, +8 authors M. V. Mazzi
  • Published 2018
  • Chemistry, Medicine
  • Toxicon
  • &NA; The chemical composition of snake venoms is a complex mixture of proteins and peptides that can be pharmacologically active. Crotamine, a cell‐penetrating peptide, has been described to have antimicrobial properties and it exerts its effects by interacting selectively with different structures, inducing changes in the ion flow pattern and cellular responses. However, its real therapeutic potential is not yet fully known. Bearing in mind that crotamine is a promising molecule in… CONTINUE READING
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