Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases.

@article{Coderch2014MechanisticII,
  title={Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases.},
  author={Claire Coderch and Emilio Lence and Antonio Pe{\'o}n and Heather K. Lamb and Alastair R. Hawkins and Federico Gago and Concepci{\'o}n Gonz{\'a}lez-Bello},
  journal={The Biochemical journal},
  year={2014},
  volume={458 3},
  pages={
          547-57
        }
}
DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans, is recognized to be an attractive target for the development of new antibacterial agents. Computational and biochemical studies that help understand in atomic detail the catalytic mechanism of these bacterial enzymes are reported in the present paper. A previously unknown key role of certain conserved residues of these enzymes, as well as… CONTINUE READING
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