Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase.

@article{Pengsuparp1995MechanisticEO,
  title={Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase.},
  author={Thitima Pengsuparp and Li Ling Cai and H{\'e}l{\`e}ne Constant and Harry H. S. Fong and L. M. Lin and A Douglas Kinghorn and John M Pezzuto and Geoffrey A. Cordell and Kristin Ingolfsdottir and Hildebert Wagner},
  journal={Journal of natural products},
  year={1995},
  volume={58 7},
  pages={1024-31}
}
Swertifrancheside [1], a new flavonone-xanthone glucoside isolated from Swertia franchetiana, 1 beta-hydroxyaleuritolic acid 3-p-hydroxybenzoate [2], a triterpene isolated from the roots of Maprounea africana, and protolichesterinic acid [3], an aliphatic alpha-methylene-gamma-lactone isolated from the lichen Cetraria islandica, were found to be potent inhibitors of the DNA polymerase activity of human immunodeficiency virus-1 reverse transcriptase (HIV-1 RT), with 50% inhibitory doses (IC50… CONTINUE READING