Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.

@article{Nagalingam2014MechanisticEO,
  title={Mechanistic elucidation of the antitumor properties of withaferin a in breast cancer.},
  author={Arumugam Nagalingam and Panjamurthy Kuppusamy and Shivendra V Singh and Dipali Sharma and Neeraj Saxena},
  journal={Cancer research},
  year={2014},
  volume={74 9},
  pages={2617-29}
}
Withaferin A (WFA) is a steroidal lactone with antitumor effects manifested at multiple levels that are mechanistically obscure. Using a phospho-kinase screening array, we discovered that WFA activated phosphorylation of the S6 kinase RSK (ribosomal S6 kinase) in breast cancer cells. Pursuing this observation, we defined activation of extracellular signal-regulated kinase (ERK)-RSK and ETS-like transcription factor 1 (Elk1)-CHOP (C-EBP homologous protein) kinase pathways in upregulating… CONTINUE READING
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