Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia.

@article{Tombaugh1990MechanisticDB,
  title={Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia.},
  author={Geoffrey C. Tombaugh and Robert Morris Sapolsky},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1990},
  volume={10 4},
  pages={
          527-35
        }
}
Excitotoxicity is believed to underlie the selective loss of vulnerable neurons after transient ischemia, while lactic acidosis seems to be the principal feature and probable cause of tissue infarcts. Primary hippocampal cultures containing both neurons and astrocytes derived from fetal rats were used to examine the relative contributions of and interactions between excitotoxic and acidotic cell injury. Hypoxia-induced damage was energy dependent and involved the N-methyl-D-aspartate (NMDA… CONTINUE READING

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