Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase.

@article{Thompson2008MechanisticCF,
  title={Mechanistic considerations for formaldehyde-induced bronchoconstriction involving S-nitrosoglutathione reductase.},
  author={Chad M Thompson and Roland C Grafstr{\"o}m},
  journal={Journal of toxicology and environmental health. Part A},
  year={2008},
  volume={71 3},
  pages={244-8}
}
Inhalation of formaldehyde vapor has long been suspected of producing airway pathophysiology such as asthma and hyperresponsivity, presumably via irritant mechanisms. Recent studies on asthma and airway biology implicate changes in nitric oxide (NO) disposition in the adverse effects of formaldehyde, principally because enzymatic reduction of the endogenous bronchodilator S-nitrosoglutathione (GSNO) is dependent upon GSNO reductase (formally designated as alcohol dehydrogenase-3, ADH3), which… CONTINUE READING
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