Mechanistic comparisons among base excision repair glycosylases.

  title={Mechanistic comparisons among base excision repair glycosylases.},
  author={Marion L. Dodson and R. Stephen Lloyd},
  journal={Free radical biology & medicine},
  volume={32 8},
The mechanisms by which various DNA glycosylases initiate the base excision repair pathways are discussed. Fundamental distinctions are made between "simple glycosylases," that do not form DNA single-strand breaks, and "glycosylases/abasic site lyases," that do form single-strand breaks. Several groupings of BER substrate sites are defined and some interactions between these groupings and glycosylase mechanisms discussed. Two characteristics are proposed to be common among all BER glycosylases… CONTINUE READING

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