Mechanistic basis of using body size and maturation to predict clearance in humans.

@article{Anderson2009MechanisticBO,
  title={Mechanistic basis of using body size and maturation to predict clearance in humans.},
  author={Brian J Anderson and Nick H G Holford},
  journal={Drug metabolism and pharmacokinetics},
  year={2009},
  volume={24 1},
  pages={25-36}
}
Growth and development are two major aspects of children not readily apparent in adults. Clearance in the paediatric population should be investigated using models that describe size, maturation and organ function influences. Size is the primary covariate and although lean body weight is argued as a better measure than total body weight, the use of different fractions of fat mass to explain how pharmacokinetic parameters vary with body composition has been proposed. Allometric scaling using an… CONTINUE READING

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