Mechanistic basis of otolith formation during teleost inner ear development.

  title={Mechanistic basis of otolith formation during teleost inner ear development.},
  author={David Wu and Jonathan B. Freund and Scott E. Fraser and Julien Vermot},
  journal={Developmental cell},
  volume={20 2},
Otoliths, which are connected to stereociliary bundles in the inner ear, serve as inertial sensors for balance. In teleostei, otolith development is critically dependent on flow forces generated by beating cilia; however, the mechanism by which flow controls otolith formation remains unclear. Here, we have developed a noninvasive flow probe using optical tweezers and a viscous flow model in order to demonstrate how the observed hydrodynamics influence otolith assembly. We show that rotational… CONTINUE READING


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Image systems for a Stokeslet inside a rigid spherical container

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