Mechanistic basis of immunotherapies for type 1 diabetes mellitus.

  title={Mechanistic basis of immunotherapies for type 1 diabetes mellitus.},
  author={Wenhao Chen and A. -Y. Xie and Lawrence K Chan},
  journal={Translational research : the journal of laboratory and clinical medicine},
  volume={161 4},
Type 1 diabetes (T1D) is an autoimmune disease for which there is no cure. The pancreatic beta cells are the source of insulin that keeps blood glucose normal. When susceptible individuals develop T1D, their beta cells are destroyed by autoimmune T lymphocytes and no longer produce insulin. T1D patients therefore depend on daily insulin injections for survival. Gene therapy in T1D aims at the induction of new islets to replace those that have been destroyed by autoimmunity. A major goal of T1D… CONTINUE READING


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