Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.

@article{Pattabiraman2010MechanisticBO,
  title={Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells.},
  author={Padmanabhan Paranji Pattabiraman and Ponugoti Vasantha Rao},
  journal={American journal of physiology. Cell physiology},
  year={2010},
  volume={298 3},
  pages={C749-63}
}
Elevated intraocular pressure arising from impaired aqueous humor drainage through the trabecular pathway is a major risk factor for glaucoma. To understand the molecular basis for Rho GTPase-mediated resistance to aqueous humor drainage, we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix (ECM) synthesis in human trabecular meshwork (TM) cells expressing a constitutively active form of RhoA (RhoAV14). TM cells expressing RhoAV14… CONTINUE READING

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Mentioned Connections BETA
TM cells expressing RhoAV14 exhibited significant increases in fibronectin , tenascin C , laminin , alpha - smooth muscle actin ( alpha - SMA ) levels , and matrix assembly in association with increased actin stress fibers and myosin light - chain phosphorylation .
TM cells expressing RhoAV14 exhibited significant increases in fibronectin , tenascin C , laminin , alpha - smooth muscle actin ( alpha - SMA ) levels , and matrix assembly in association with increased actin stress fibers and myosin light - chain phosphorylation .
ActinsSibling in is aMyosin ATPase
TM cells expressing RhoAV14 exhibited significant increases in fibronectin , tenascin C , laminin , alpha - smooth muscle actin ( alpha - SMA ) levels , and matrix assembly in association with increased actin stress fibers and myosin light - chain phosphorylation .
Myosin ATPaseSibling in is aActins
TM cells expressing RhoAV14 exhibited significant increases in fibronectin , tenascin C , laminin , alpha - smooth muscle actin ( alpha - SMA ) levels , and matrix assembly in association with increased actin stress fibers and myosin light - chain phosphorylation .
TM cells expressing RhoAV14 exhibited significant increases in fibronectin , tenascin C , laminin , alpha - smooth muscle actin ( alpha - SMA ) levels , and matrix assembly in association with increased actin stress fibers and myosin light - chain phosphorylation .
To understand the molecular basis for Rho GTPase - mediated resistance to aqueous humor drainage , we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix ( ECM ) synthesis in human trabecular meshwork ( TM ) cells expressing a constitutively active form of RhoA ( RhoAV14 ) .
To understand the molecular basis for Rho GTPase - mediated resistance to aqueous humor drainage , we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix ( ECM ) synthesis in human trabecular meshwork ( TM ) cells expressing a constitutively active form of RhoA ( RhoAV14 ) .
To understand the molecular basis for Rho GTPase - mediated resistance to aqueous humor drainage , we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix ( ECM ) synthesis in human trabecular meshwork ( TM ) cells expressing a constitutively active form of RhoA ( RhoAV14 ) .
To understand the molecular basis for Rho GTPase - mediated resistance to aqueous humor drainage , we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix ( ECM ) synthesis in human trabecular meshwork ( TM ) cells expressing a constitutively active form of RhoA ( RhoAV14 ) .
To understand the molecular basis for Rho GTPase - mediated resistance to aqueous humor drainage , we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix ( ECM ) synthesis in human trabecular meshwork ( TM ) cells expressing a constitutively active form of RhoA ( RhoAV14 ) .
To understand the molecular basis for Rho GTPase - mediated resistance to aqueous humor drainage , we investigated the possible interrelationship between actomyosin contractile properties and extracellular matrix ( ECM ) synthesis in human trabecular meshwork ( TM ) cells expressing a constitutively active form of RhoA ( RhoAV14 ) .
TM cells expressing RhoAV14 exhibited significant increases in fibronectin , tenascin C , laminin , alpha - smooth muscle actin ( alpha - SMA ) levels , and matrix assembly in association with increased actin stress fibers and myosin light - chain phosphorylation .
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