Mechanistic aspects the dioxin (aryl hydrocarbon) receptor

@article{Poellinger2000MechanisticAT,
  title={Mechanistic aspects the dioxin (aryl hydrocarbon) receptor},
  author={Lorenz Poellinger},
  journal={Food Additives \& Contaminants},
  year={2000},
  volume={17},
  pages={261 - 266}
}
  • L. Poellinger
  • Published 1 April 2000
  • Biology, Chemistry
  • Food Additives & Contaminants
The Ah receptor mediates the toxicological responses of 2,3,7,8-TCDD and related compounds. Receptor-deficient animals were shown to be resistant to the toxic effects of dioxin, although there is also evidence for the existence of a receptor-independent pathway for dioxin-induced toxicity. In the cytosol the receptor is present in a non-activated ligand binding conformation. Association with Arnt in the nucleus turns the receptor complex into a ligand activated form. The physiological role of… 

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...

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