Mechanistic aspects of the release of levamisole hydrochloride from biodegradable polymers.

@article{Gallagher2000MechanisticAO,
  title={Mechanistic aspects of the release of levamisole hydrochloride from biodegradable polymers.},
  author={K. M. Gallagher and O. I. Corrigan},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2000},
  volume={69 2},
  pages={
          261-72
        }
}
The release of levamisole hydrochloride from poly-DL-lactide-co-glycolide compacts prepared at 5, 10 and 20% drug loading using two different particle size fractions of drug (90-125 and 125-250 microm) was investigated. Release profiles were significantly different from those previously reported for compacts prepared using the base form of the drug. Release was found to occur in a biphasic manner, with an initial fast release phase followed by a slower polymer degradation controlled release… CONTINUE READING
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