Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent

  title={Mechanistic aspects of the cytotoxic activity of glufosfamide, a new tumour therapeutic agent},
  author={Hasan Seker and Barbara Bertram and Alexander B{\"u}rkle and Bernd Kaina and J{\"o}rg Pohl and Hermann Koepsell and Manfred Wiessler},
  journal={British Journal of Cancer},
  pages={629 - 634}
β- D -Glucosyl-ifosfamide mustard (D 19575, glc-IPM, INN = glufosfamide) is a new agent for cancer chemotherapy. Its mode of action, which is only partly understood, was investigated at the DNA level. In the breast carcinoma cell line MCF7 glufosfamide inhibited both the synthesis of DNA and protein in a dose-dependent manner, as shown by the decreased incorporation of [3H-methyl]-thymidine into DNA and [14C]-methionine into protein of these cells. Treatment of MCF7 cells with 50 μM… CONTINUE READING
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