Mechanistic approaches for evaluating the toxicity of reactive organochlorines and epoxides in green algae

@article{Niederer2004MechanisticAF,
  title={Mechanistic approaches for evaluating the toxicity of reactive organochlorines and epoxides in green algae},
  author={Christian Niederer and Renata Behra and Angela Harder and René P. Schwarzenbach and Beate I. Escher},
  journal={Environmental Toxicology and Chemistry},
  year={2004},
  volume={23}
}
Reactive electrophilic chemicals, such as reactive organochlorine compounds or epoxides, react specifically with a broad spectrum of nucleophilic biomolecules, including proteins and DNA. Conventional toxicity tests for algae, involving the observation of growth inhibition, i.e., the inhibition of cell multiplication, after several days, yield unreliable information for risk assessment because reactive compounds hydrolyze to different extents during the exposure period. The diversity of their… 

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