Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.

@article{Mayans2013MechanisticAF,
  title={Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.},
  author={Olga Mayans and Guy M. Benian and Felix Simkovic and Daniel J. Rigden},
  journal={Biochemical Society transactions},
  year={2013},
  volume={41 4},
  pages={1066-71}
}
The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinity. In the present article, we discuss the speciation of mechanosensory mechanisms in titin-like kinases, their scaffolding properties and the kinase/pseudokinase domain variations… CONTINUE READING
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Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase

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