Mechanistic and functional differentiation of tapentadol and tramadol

  title={Mechanistic and functional differentiation of tapentadol and tramadol},
  author={R. Raffa and H. Buschmann and T. Christoph and G. Eichenbaum and W. Englberger and C. Flores and T. Hertrampf and B. K{\"o}gel and K. Schiene and W. Strassburger and R. Terlinden and T. M. Tzschentke},
  journal={Expert Opinion on Pharmacotherapy},
  pages={1437 - 1449}
  • R. Raffa, H. Buschmann, +9 authors T. M. Tzschentke
  • Published 2012
  • Medicine
  • Expert Opinion on Pharmacotherapy
  • Introduction: Many opioid analgesics share common structural elements; however, minor differences in structure can result in major differences in pharmacological activity, pharmacokinetic profile, and clinical efficacy and tolerability. Areas covered: This review compares and contrasts the chemistry, pharmacodynamics, pharmacokinetics, and CNS ‘functional activity' of tapentadol and tramadol, responsible for their individual clinical utilities. Expert opinion: The distinct properties of… CONTINUE READING
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