Mechanistic and functional differentiation of tapentadol and tramadol

@article{Raffa2012MechanisticAF,
  title={Mechanistic and functional differentiation of tapentadol and tramadol},
  author={R. Raffa and H. Buschmann and T. Christoph and G. Eichenbaum and W. Englberger and C. Flores and T. Hertrampf and B. K{\"o}gel and K. Schiene and W. Strassburger and R. Terlinden and T. M. Tzschentke},
  journal={Expert Opinion on Pharmacotherapy},
  year={2012},
  volume={13},
  pages={1437 - 1449}
}
  • R. Raffa, H. Buschmann, +9 authors T. M. Tzschentke
  • Published 2012
  • Medicine
  • Expert Opinion on Pharmacotherapy
  • Introduction: Many opioid analgesics share common structural elements; however, minor differences in structure can result in major differences in pharmacological activity, pharmacokinetic profile, and clinical efficacy and tolerability. Areas covered: This review compares and contrasts the chemistry, pharmacodynamics, pharmacokinetics, and CNS ‘functional activity' of tapentadol and tramadol, responsible for their individual clinical utilities. Expert opinion: The distinct properties of… CONTINUE READING
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    • 30
    • Highly Influenced
    PharmGKB summary: tramadol pathway.
    • 45
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    • 61
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 78 REFERENCES
    In vitro and in vivo characterization of tapentadol metabolites.
    • 61
    [Pharmacology of tramadol].
    • 163
    Tapentadol and its two mechanisms of action: Is there a new pharmacological class of centrally‐acting analgesics on the horizon?
    • 108
    • Highly Influential
    Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia
    • 102
    • PDF
    Role of active metabolites in the use of opioids
    • 94
    • PDF
    A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain.
    • 167
    • PDF