Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma.

@article{Fang2015MechanisticAB,
  title={Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma.},
  author={Qin-Liang Fang and Yi-Rui Yin and Cheng-Rong Xie and Sheng Zhang and Wen-xiu Zhao and Chao Pan and Xiaomin Wang and Zhen-yu Yin},
  journal={International journal of oncology},
  year={2015},
  volume={46 2},
  pages={782-90}
}
Dysregulation of growth factor signaling plays a pivotal role in controlling the malignancy phenotype and progression of hepatocellular carcinoma (HCC). However, the precise oncogenic mechanisms underlying transcription regulation of certain tumor suppressor genes (TSGs) by growth factors are poorly understood. In the present study, we report a novel insulin-like growth factor 1 (IGF1) pathway that mediates de novo DNA methylation and TSG (such as DLC1 and CHD5) silencing by upregulation of the… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 31 references

Gene transfer of IGF1 attenuates hepatocellular apoptosis after bile duct ligation

  • K Pi-Chieh Wang, LM Lee, TJ Lin
  • J Surg Res
  • 2011

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