Mechanistic Studies of Copper-Catalyzed Alkene Aziridination

@inproceedings{Brandt2000MechanisticSO,
  title={Mechanistic Studies of Copper-Catalyzed Alkene Aziridination},
  author={Peter Brandt and Mikael J. S{\"o}dergren and Pher G Andersson and Per-Ola Norrby},
  year={2000}
}
The mechanism of the copper-catalyzed aziridination of alkenes using [N-(p-toluenesulfonyl)imino]phenyliodinane (PhINTs) as the nitrene source has been elucidated by a combination of hybrid density functional theory calculations (B3LYP) and kinetic experiments. The calculations could assign a Cu(I)/Cu(III)-cycle to the reaction and demonstrate why a higher oxidation state of copper cannot catalyze the reaction. A mechanism whereby Cu(II)−catalyst precursors can enter the Cu(I)/Cu(III)-cycle is… CONTINUE READING

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