Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.

@article{McCabe2015MechanisticRT,
  title={Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.},
  author={Nuala McCabe and Conor Hanna and Steven M. Walker and David D Gonda and Jie Li and Katarina Wikstrom and Kienan I. Savage and Karl Terence Butterworth and Clark C Chen and D. Paul Harkin and Kevin M Prise and Richard D. Kennedy},
  journal={Cancer research},
  year={2015},
  volume={75 11},
  pages={2159-65}
}
Ataxia telangiectasia mutated (ATM) is an important signaling molecule in the DNA damage response (DDR). ATM loss of function can produce a synthetic lethal phenotype in combination with tumor-associated mutations in FA/BRCA pathway components. In this study, we took an siRNA screening strategy to identify other tumor suppressors that, when inhibited, similarly sensitized cells to ATM inhibition. In this manner, we determined that PTEN and ATM were synthetically lethal when jointly inhibited… CONTINUE READING
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Mechanistic Rationale to Target PTEN - Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM

N. McCabe
2015

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