Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes

@article{Sarwar2020MechanisticPA,
  title={Mechanistic Pathways and Molecular Targets of Plant-Derived Anticancer ent-Kaurane Diterpenes},
  author={Md. Shahid Sarwar and Yi-Xuan Xia and Zheng-Ming Liang and Siu Wai Tsang and Hong-Jie Zhang},
  journal={Biomolecules},
  year={2020},
  volume={10}
}
Since the first discovery in 1961, more than 1300 ent-kaurane diterpenoids have been isolated and identified from different plant sources, mainly the genus Isodon. Chemically, they consist of a perhydrophenanthrene subunit and a cyclopentane ring. A large number of reports describe the anticancer potential and mechanism of action of ent-kaurane compounds in a series of cancer cell lines. Oridonin is one of the prime anticancer ent-kaurane diterpenoids that is currently in a phase-I clinical… Expand
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