Mechanistic Insights into the Allosteric Modulation of Opioid Receptors by Sodium Ions

Abstract

The idea of sodium ions altering G-protein-coupled receptor (GPCR) ligand binding and signaling was first suggested for opioid receptors (ORs) in the 1970s and subsequently extended to other GPCRs. Recently published ultra-high-resolution crystal structures of GPCRs, including that of the δ-OR subtype, have started to shed light on the mechanism underlying… (More)
DOI: 10.1021/bi5006915

Topics

5 Figures and Tables