Mechanistic Insight into the Nitrosylation of the [4Fe−4S] Cluster of WhiB-like Proteins

@inproceedings{Crack2011MechanisticII,
  title={Mechanistic Insight into the Nitrosylation of the [4Fe−4S] Cluster of WhiB-like Proteins},
  author={Jason C. Crack and Laura J. Smith and Melanie R. Stapleton and Jamie N T Peck and Nicholas J. Watmough and Mark J. Buttner and Roger S Buxton and Jeffrey Green and Vasily S Oganesyan and Andrew James Thomson and Nick E Le Brun},
  booktitle={Journal of the American Chemical Society},
  year={2011}
}
The reactivity of protein bound iron-sulfur clusters with nitric oxide (NO) is well documented, but little is known about the actual mechanism of cluster nitrosylation. Here, we report studies of members of the Wbl family of [4Fe-4S] containing proteins, which play key roles in regulating developmental processes in actinomycetes, including Streptomyces and Mycobacteria, and have been shown to be NO responsive. Streptomyces coelicolor WhiD and Mycobacterium tuberculosis WhiB1 react extremely… CONTINUE READING