Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion.

Abstract

The mechanistic imperatives for catalysis of deprotonation of α-carbonyl carbon by triosephosphate isomerase (TIM) are discussed. There is a strong imperative to reduce the large thermodynamic barrier for deprotonation of carbon to form an enediolate reaction intermediate; and, a strong imperative for specificity in the expression of the intrinsic… (More)

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@article{Zhai2014MechanisticIF, title={Mechanistic Imperatives for Deprotonation of Carbon Catalyzed by Triosephosphate Isomerase: Enzyme-Activation by Phosphite Dianion.}, author={Xiang Zhai and M. Merced Malabanan and Tina L. Amyes and John P Richard}, journal={Journal of physical organic chemistry}, year={2014}, volume={27 4}, pages={269-276} }