Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization

  title={Mechanistic Analysis of Cocrystal Dissolution as a Function of pH and Micellar Solubilization},
  author={Fengjuan Cao and Gordon L Amidon and Na{\'i}r Rodr{\'i}guez-Hornedo and Gregory E. Amidon},
  journal={Molecular Pharmaceutics},
  pages={1030 - 1046}
The purpose of this work is to provide a mechanistic understanding of the dissolution behavior of cocrystals under the influence of ionization and micellar solubilization. Mass transport models were developed by applying Fick’s law of diffusion to dissolution with simultaneous chemical reactions in the hydrodynamic boundary layer adjacent to the dissolving cocrystal surface to predict the pH at the dissolving solid–liquid interface (i.e., interfacial pH) and the flux of cocrystals. To evaluate… 
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