Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia.

@article{Hirao2013MechanisticM,
  title={Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia.},
  author={Atsushi Hirao and Takayuki Hoshii},
  journal={Cancer science},
  year={2013},
  volume={104 8},
  pages={977-82}
}
Mechanistic/mammalian target protein of rapamycin (mTOR) is an evolutionarily conserved kinase that plays a critical role in sensing and responding to environmental determinants such as nutrient availability, energy sufficiency, stress, and growth factor concentration. mTOR participates in two complexes, designated mTOR complex 1 (mTORC1) and 2 (mTORC2), both of which phosphorylate multiple substrates. Recent studies have revealed that the fine-tuning activity of mTOR complexes contributes to… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

References

Publications referenced by this paper.
Showing 1-10 of 84 references

Tempo - ral Changes in PTEN and mTORC 2 regulation of hematopoietic stem cell self - renewal and leukemia suppression

JK Altman, LC Platanias
Cell Stem Cell • 2012

Similar Papers

Loading similar papers…