Mechanisms whereby propofol mediates peripheral vasodilation in humans. Sympathoinhibition or direct vascular relaxation?

@article{Robinson1997MechanismsWP,
  title={Mechanisms whereby propofol mediates peripheral vasodilation in humans. Sympathoinhibition or direct vascular relaxation?},
  author={Brian J. Robinson and Thomas J Ebert and Thomas J O'Brien and M D Colinco and Michael Muzi},
  journal={Anesthesiology},
  year={1997},
  volume={86 1},
  pages={64-72}
}
BACKGROUND Anesthetic induction and maintenance with propofol are associated with decreased blood pressure that is, in part, due to decreased peripheral resistance. Several possible mechanisms whereby propofol could reduce peripheral resistance include a direct action of propofol on vascular smooth muscle, an inhibition of sympathetic activity to the vasculature, or both. This study examined these two possibilities in humans by measuring the forearm vascular responses to infusions of propofol… CONTINUE READING

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