Mechanisms whereby exogenous adenine nucleotides improve rabbit renal proximal function during and after anoxia.

@article{Mandel1988MechanismsWE,
  title={Mechanisms whereby exogenous adenine nucleotides improve rabbit renal proximal function during and after anoxia.},
  author={Lazaro J. Mandel and Takahiro Takano and Stephen P. Soltoff and S E Murdaugh},
  journal={The Journal of clinical investigation},
  year={1988},
  volume={81 4},
  pages={1255-64}
}
When a suspension of rabbit proximal tubules is subjected to anoxia, ATP falls by 80-90% during 40 min of anoxia, and upon reoxygenation (reox) the cells only recover 25-50% of their initial ATP. Addition of Mg-ATP (magnesium chloride-treated ATP), Mg-ADP, or Mg-AMP (five aliquots of 200 nmol/ml added 10 min apart) during anoxia causes complete recovery of ATP levels, and respiratory and transport function after 40 min of reox. Similar additions of adenosine (ADO), or inosine (INO), or Mg-ATP… CONTINUE READING
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