Mechanisms underlying the localisation of mast cells in tissues.

@article{Collington2011MechanismsUT,
  title={Mechanisms underlying the localisation of mast cells in tissues.},
  author={Sarah J. Collington and Timothy J. Williams and Charlotte L. Weller},
  journal={Trends in immunology},
  year={2011},
  volume={32 10},
  pages={
          478-85
        }
}
Mast cells are tissue-resident cells best known for their role in allergy and host defence against helminth parasites. They are involved in responses against other pathogenic infections, wound healing and inflammatory disease. Committed mast cell progenitors are released from the bone marrow into the circulation, from where they are recruited into tissues to complete their maturation under the control of locally produced cytokines and growth factors. Directed migration occurs at distinct stages… CONTINUE READING
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