Mechanisms underlying the inhibitory effect of propofol on the contraction of canine airway smooth muscle.


BACKGROUND Propofol has been shown to produce relaxation of preconstricted airway smooth muscle. Although the inhibition of calcium mobilization is supposed to be the major mechanism of action, the whole picture of the mechanisms is not completely clear. METHODS Contractile response was performed using canine tracheal rings. The effects of propofol on… (More)