Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF/KIT protein interactions and the downstream effector, MITF-M.

@article{Kitamura2004MechanismsUT,
  title={Mechanisms underlying the dysfunction of melanocytes in vitiligo epidermis: role of SCF/KIT protein interactions and the downstream effector, MITF-M.},
  author={Reiko Kitamura and Katsuhiko Tsukamoto and Kazutoshi Harada and Akira Shimizu and Shinji Shimada and Takeshi Kobayashi and Genji Imokawa},
  journal={The Journal of pathology},
  year={2004},
  volume={202 4},
  pages={463-75}
}
Little is known about the mechanisms involved in the dysfunction of melanocytes in vitiligo epidermis. It is hypothesized that some cytokine/receptor interactions may be affected, resulting in dysfunction and/or loss of melanocytes. This study has compared the expression of endothelin (ET)-1, the ET-1 receptor (ET(B)R), granulocyte macrophage colony stimulating factor (GM-CSF), stem cell factor (SCF), the SCF receptor (KIT protein), tyrosinase, and S100 alpha between lesional and non-lesional… CONTINUE READING

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