Mechanisms underlying the diabetes-induced hyporeactivity of the rabbit carotid artery to atrial natriuretic peptide.

@article{Marrachelli2011MechanismsUT,
  title={Mechanisms underlying the diabetes-induced hyporeactivity of the rabbit carotid artery to atrial natriuretic peptide.},
  author={Vannina Gonz{\'a}lez Marrachelli and Francisco Javier Forcada Miranda and Jos{\'e} Alberto Maroto Centeno and Ignacio Alberto Miranda and Mar{\'i}a Castell{\'o}-Ruiz and Mar{\'i}a Teresa Castillo Burguete and Teresa Jover-Mengual and J. M Berto Salom and Germ{\'a}n Torregrosa and Enrique Alborch},
  journal={Pharmacological research},
  year={2011},
  volume={63 3},
  pages={
          190-8
        }
}
Atrial natriuretic peptide (ANP) plays an important role in the pathophysiology of the vascular complications in diabetes. The working hypothesis was that diabetes might modify the vascular actions of ANP in isolated rabbit carotid arteries and the mechanisms involved in these actions. ANP (10(-12)-10(-7)M) induced a relaxation of precontracted carotid arteries, which was lower in diabetic than in control rabbits. In arteries from both groups of animals, endothelium removal increased the ANP… CONTINUE READING
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