Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis.

@article{Borch2006MechanismsUT,
  title={Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis.},
  author={Julie Borch and Stine Broeng Metzdorff and Anne Marie Vinggaard and Leon J. S. Brokken and Majken Dalgaard},
  journal={Toxicology},
  year={2006},
  volume={223 1-2},
  pages={144-55}
}
Diethylhexyl phthalate (DEHP) is widely used as a plasticizer in consumer products and is known to disturb the development of the male reproductive system in rats. The mechanisms by which DEHP exerts these effects are not yet fully elucidated, though some of the effects are related to reduced fetal testosterone production. The present study investigated the effects of four different doses of DEHP on fetal testicular histopathology, testosterone production and expression of proteins and genes… CONTINUE READING

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Diethylhexyl phthalate ( DEHP ) is widely used as a plasticizer in consumer products and is known to disturb the development of the male reproductive system in rats .
Immunohistochemistry showed clear reductions of StAR , PBR , P450scc and PPARgamma protein levels in fetal Leydig cells , indicating that DEHP affects regulation of certain steps in cholesterol transport and steroid synthesis .
The present study investigated the effects of four different doses of DEHP on fetal testicular histopathology , testosterone production and expression of proteins and genes involved in steroid synthesis in fetal testes .
The present study investigated the effects of four different doses of DEHP on fetal testicular histopathology , testosterone production and expression of proteins and genes involved in steroid synthesis in fetal testes .
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