Mechanisms underlying subunit independence in pyramidal neuron dendrites.

  title={Mechanisms underlying subunit independence in pyramidal neuron dendrites.},
  author={Bardia F. Behabadi and Bartlett W. Mel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 1},
Pyramidal neuron (PN) dendrites compartmentalize voltage signals and can generate local spikes, which has led to the proposal that their dendrites act as independent computational subunits within a multilayered processing scheme. However, when a PN is strongly activated, back-propagating action potentials (bAPs) sweeping outward from the soma synchronize dendritic membrane potentials many times per second. How PN dendrites maintain the independence of their voltage-dependent computations… CONTINUE READING
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