Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.

@article{Miller2009MechanismsUS,
  title={Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.},
  author={Mark S. Miller and Peter C Vanburen and Martin Lewinter and Stewart H. Lecker and Donald E. Selby and Bradley M. Palmer and David W. Maughan and Philip A. Ades and Michael J. Toth},
  journal={Circulation. Heart failure},
  year={2009},
  volume={2 6},
  pages={700-6}
}
BACKGROUND Patients with chronic heart failure (HF) frequently experience skeletal muscle weakness that limits physical function. The mechanisms underlying muscle weakness, however, have not been clearly defined. METHODS AND RESULTS This study examined the hypothesis that HF promotes a loss of myosin protein from single skeletal muscle fibers, which in turn reduces contractile performance. Ten patients with chronic HF and 10 controls were studied. Muscle atrophy was not evident in patients… CONTINUE READING
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Diaphragm singlefiber weakness and loss of myosin in congestive heart failure rats

  • HW vanHees, HF vanderHeijden, +5 authors PN Dekhuijzen
  • Am J Physiol Heart Circ Physiol
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