Mechanisms underlying losses of heterozygosity in human colorectal cancers.

  title={Mechanisms underlying losses of heterozygosity in human colorectal cancers.},
  author={Sam Thiagalingam and Steve Laken and James K. V. Willson and Sanford D Markowitz and Ken W Kinzler and Bert Vogelstein and Christoph Lengauer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 5},
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for losses of heterozygosity in such tumors. Here we report a detailed investigation of the five chromosomes lost most frequently in human colorectal cancers. A total of 10,216 determinations were made with 88 microsatellite markers, revealing 245 chromosomal loss events. The mechanisms of loss were… CONTINUE READING