Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells.

@article{OShea2010MechanismsUL,
  title={Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells.},
  author={John J O'Shea and William E. Paul},
  journal={Science},
  year={2010},
  volume={327 5969},
  pages={
          1098-102
        }
}
CD4+ T cells are critical for host defense but are also major drivers of immune-mediated disease. These T cells specialize to become distinct subsets and produce restricted patterns of cytokines, which are tailored to combat various microbial pathogens. Although classically viewed as distinct lineages, recent work calls into question whether helper CD4+ T cell subsets are more appropriately viewed as terminally differentiated cells or works in progress. Herein, we review recent advances that… CONTINUE READING

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 612 CITATIONS, ESTIMATED 51% COVERAGE

Biological Insights from Geometry and Structure of Single-Cell Data

VIEW 8 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

The Role of Macrophages in the Pathogenesis of ALI/ARDS

  • Mediators of inflammation
  • 2018
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

T helper type 17 cells in immune-mediated glomerular disease

VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Immune Modulation after T-Cell Depletion Therapy in Kidney Transplant Patients

VIEW 15 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Pro-inflammatory/Th1 gene expression shift in high glucose stimulated mesangial cells and tubular epithelial cells.

  • Biochemical and biophysical research communications
  • 2014
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 45 Highly Influenced Citations

  • Averaged 40 Citations per year from 2017 through 2019