Mechanisms underlying ketamine-induced synaptic depression in rat hippocampus-medial prefrontal cortex pathway.

@article{Kamiyama2011MechanismsUK,
  title={Mechanisms underlying ketamine-induced synaptic depression in rat hippocampus-medial prefrontal cortex pathway.},
  author={Hidekazu Kamiyama and Mitsuyuki Matsumoto and Satoru Otani and S-i Kimura and K Shimamura and Shyhei Ishikawa and Yuchio Yanagawa and Hiroko Togashi},
  journal={Neuroscience},
  year={2011},
  volume={177},
  pages={159-69}
}
The non-competitive N-methyl-D-aspartate NMDA receptor antagonist ketamine, a dissociative anesthetic capable of inducing analgesia, is known to have psychotomimetic actions, but the detailed mechanisms remain unclear because of its complex properties. The present study elucidated neural mechanisms of the effect of ketamine, at doses that exert psychotomimetic effects without anesthetic and analgesic effects, by evaluating cortical synaptic responses in vivo. Systemic administration (i.p.) of… CONTINUE READING
19 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…