Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus.

@article{Mulkey1992MechanismsUI,
  title={Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus.},
  author={Rosel M. Mulkey and Robert C Malenka},
  journal={Neuron},
  year={1992},
  volume={9 5},
  pages={967-75}
}
The mechanisms responsible for long-lasting, activity-dependent decreases in synaptic efficacy are not well understood. We have examined the initial steps required for the induction of long-term depression (LTD) in CA1 pyramidal cells by repetitive low frequency (1 Hz) synaptic stimulation. This form of LTD was synapse specific, was saturable, and required activation of post-synaptic NMDA receptors. Loading CA1 cells with the Ca2+ chelator BAPTA prevented LTD, whereas lowering extracellular Ca2… CONTINUE READING
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