Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.

@article{Frana2014MechanismsUH,
  title={Mechanisms underlying hypertriglyceridemia in rats with monosodium L-glutamate-induced obesity: evidence of XBP-1/PDI/MTP axis activation.},
  author={Lucas Martins França and Larissa Nara Costa Freitas and Vinicyus Teles Chagas and Caio Fernando Ferreira Co{\^e}lho and Wermerson Assunç{\~a}o Barroso and Graciomar Conceiç{\~a}o Costa and Lucilene A Silva and Victor Debbas and Francisco Rafael Martins Laurindo and Antonio Marcus de Andrade Paes},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={443 2},
  pages={725-30}
}
Non-alcoholic fatty liver disease (NAFLD) is intimately associated with insulin resistance and hypertriglyceridemia, whereas many of the mechanisms underlying this association are still poorly understood. In the present study, we investigated the relationship between microsomal triglyceride transfer protein (MTP) and markers of endoplasmic reticulum (ER) stress in the liver of rats subjected to neonatal monosodium L-glutamate (MSG)-induced obesity. At age 120 days old, the MSG-obese animals… CONTINUE READING
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