Mechanisms underlying gastric antiulcerative activity of nitroxides in rats.

@article{Samuni1999MechanismsUG,
  title={Mechanisms underlying gastric antiulcerative activity of nitroxides in rats.},
  author={Amram Samuni and Fanny Karmeli and M Moshen and Dr Daniel Rachmilewitz},
  journal={Free radical research},
  year={1999},
  volume={30 2},
  pages={133-40}
}
Reactive oxygen-derived species and redox-active metals are implicated in mediation of the pathogenesis of gastric mucosal damage and ulceration. Therefore, common strategies of intervention employ metal chelators, antioxidative enzymes, and low-molecular-weight antioxidants (LMWA). The aim of the present study was to elaborate the mechanism(s) responsible for the protection provided by nitroxide radicals in the experimental model of gastric ulceration. Fasted male rats were treated ig with 1… CONTINUE READING