Mechanisms underlying expression of Tn10 encoded tetracycline resistance.

@article{Hillen1994MechanismsUE,
  title={Mechanisms underlying expression of Tn10 encoded tetracycline resistance.},
  author={W. Hillen and Christian Berens},
  journal={Annual review of microbiology},
  year={1994},
  volume={48},
  pages={
          345-69
        }
}
Tetracycline-resistance determinants encoding active efflux of the drug are widely distributed in gram-negative bacteria and unique with respect to genetic organization and regulation of expression. Each determinant consists of two genes called tetA and tetR, which are oriented with divergent polarity, and between them is a central regulatory region with overlapping promoters and operators. The amino acid sequences of the encoded proteins are 43-78% identical. The resistance protein TetA is a… CONTINUE READING
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