Mechanisms underlying excessive esophageal acid exposure in patients with gastroesophageal reflux disease

Abstract

The cause of reflux esophagitis (RE) is excessive esophageal acid exposure. Acid reflux and acid clearance after acid reflux are important factors related to excessive esophageal acid exposure. The main mechanism responsible for acid reflux is transient lower esophageal sphincter relaxation (TLESR), which is LES relaxation not associated with swallowing… (More)
DOI: 10.1007/s10388-017-0575-7

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