Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery.

@article{Matsumoto2004MechanismsUE,
  title={Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery.},
  author={Takayuki Matsumoto and Shintaro Yoshiyama and Tsuneo Kobayashi and Katsuo Kamata},
  journal={Peptides},
  year={2004},
  volume={25 11},
  pages={1985-94}
}
We investigated the influence of streptozotocin-induced diabetes on the responsiveness of the rat basilar artery to endothelin-1 (ET-1) and nitric oxide (NO), which is known to counteract ET-1. In basilar arteries isolated from diabetic rats: (a) the ET-1-induced contraction was enhanced, (b) the contraction induced by N(G)-nitro-l-arginine [a nitric oxide… CONTINUE READING