Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state.

@article{Chen2005MechanismsUE,
  title={Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state.},
  author={Yong Chen and Guangwen Li and Congying Wang and Yanping Gu and L M Huang},
  journal={Pain},
  year={2005},
  volume={119 1-3},
  pages={38-48}
}
P2X3 and P2X2/3 receptors in dorsal root ganglia (DRG) appear to participate in producing nociceptive responses after nerve injury. However, the mechanisms underlying the receptor-mediated nociception in the neuropathic state remain unclear. Using spared nerve injury (SNI) rats, we found that allodynic and nocifensive (flinch) behavioral responses developed after injury can be reversed by P2X receptor antagonists, indicating an involvement of P2X receptors. Immunocytochemical studies revealed… CONTINUE READING
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