Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML

@article{Salesse2002MechanismsUA,
  title={Mechanisms underlying abnormal trafficking and expansion of malignant progenitors in CML: BCR/ABL-induced defects in integrin function in CML},
  author={St{\'e}phanie Salesse and Catherine M. Verfaillie},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={8605-8611}
}
Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell characterized by the presence of the Philadelphia chromosome (Ph) (Nowell and Hungerford, 1960) and the formation of the BCR/ABL fusion gene (Rowley, 1973), encoding the p210 oncoprotein. Clinically, CML is characterized by the premature circulation of a massively expanded immature myeloid progenitor and precursor pool in the blood. At the cellular level, CML is characterized by an increased proliferation… CONTINUE READING
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